My paranormal romance that’s currently on submission is mainly set in a fictional small city, Cameron City, OH. A few scenes are in a fictional part of Indianapolis.
The one I’m working on now, same series, is set in Indianapolis, a fictional part of Louisville, KY, and a fictional rural community, Drake Hollow, KY.
Setting plays a larger part in my WIP than it has in any of my others. Drake Hollow is a community made up exclusively of weredragons, where they don’t have to hide what they are.
On a smaller scale, I use setting, on a scene by scene basis, almost as another character, with minimal description.